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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 25, Number 8
BKCSDE 25(8)
August 20, 2004 

The Study of Doxorubicin and its Complex with DNA by SERS and UV-resonance Raman Spectroscopy
Chul Jae Lee, Jae Soo Kang, Mak Soon Kim, Kwang Pill Lee, Mu Sang Lee*
UV-resonance Raman spectroscopy, SERS, DNA, Doxorubicin
The interaction of the antitumour agent doxorubicin with calf thymus DNA is investigated in an aqueous solution at a pH level of 6-7 with molar ratios of 1/10. A UV-resonance Raman spectroscopy and surface enhanced Raman spectroscopy are used to determine the doxorubicin binding sites and the structural variations of doxorubicin-DNA complexes in an aqueous solution. Doxorubicin intercalates with adenine and guanine via a hydrogen bond formation between the N7 positions of purine bases and the hydroxyl group of doxorubicin.
1211 - 1216
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