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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 25, Number 7
BKCSDE 25(7)
July 20, 2004 

Alkoxybenzylcyanoguanidine Analogs as a Novel Class of Inhibitors for Restenosis
Sunkyung Lee, Kyu Yang Yi*, Sun Kyung Hwang, Jeehee Suh, Byung Ho Lee, Sung-eun Yoo
Alkoxybenzylcyanoguanidine, PTCA, Restenosis, Cell proliferation, Intimal hyperplasia
A novel class of alkoxybenzylcyanoguanidine analogs as the inhibitors of restenosis was discovered, which showed the inhibitory effects on angiotensin II-induced cell proliferation, determined by [3H]thymidine incorporation method. The compound, N'-(4-nitrophenyl)guanidine analog 19, showed 62% inhibition of [3H]thymidine incorporation at 1 μM concentration. In addition, the compound 19 inhibited intimal thickening dose-dependently after balloon injury, which suggests the therapeutic potential for restenosis.
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