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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 25, Number 7
BKCSDE 25(7)
July 20, 2004

Title	Synthesis of Certain 6-(Arylthio)uracils and Related Derivatives as Potential Antiviral Agents
Author	Ali A. El-Emam*, Mohamed A. M. Massoud, Eman R. El-Bendary, Magda A. El-Sayed
Keywords	Substituted uracils, Benzothiopyrano[2,3-d]pyrimidine, Pyrimido[5,4-f]benzo[1,4]thiazepines, Antiviral activity, Cytotoxicity
Abstract	New series of 6-(arylthio)uracils, 6-(4-substituted-1-piperazinyl)uracils, 2,4,5-trioxo-1H,3H-benzothiopyrano[2,3-d]pyrimidine and 5-aryl-2,4-dioxo-1H,3H-pyrimido[5,4-f]benzo[1,4]thiazepines have been prepared and screened for their in vitro activity against herpes simplex-1 virus (HSV-1) and human immunodeficiency virus-1 (HIV-1). The in vitro cytotoxic activity was also evaluated. The results of biological testing revealed that compound 5b showed marginal activity against HSV-1, while compounds 5b and 5f exhibited marginal activity against HIV-1. The rest of the tested compounds were found devoid of antiviral activity against both HSV-1 and HIV-1.
Page	991 - 996
Full Text	PDF

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