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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 25, Number 5
BKCSDE 25(5)
May 20, 2004 

 
Title
The First Synthesis of Dually Modified Southern-Mimicking Nucleoside: 4\'-Methyl Branched and Bicyclo [3
Author
Kwan Woo Kim, Joon Hee Hong*
Keywords
Locked-nucleoside, [3,3]-Sigmatropic rearrangement, Curtius reaction, Antiviral agents
Abstract
This paper reports the stereoselective synthesis of a novel nucleoside, 4'-methyl branched and bicyclo [3.1.0] hexane locked-nucleoside 12, using a sequential [3,3]-sigmatropic rearrangement/carbene cycloaddition reaction/Curtius reaction strategy with a high stereoselectivity.
Page
668 - 0
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