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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 25, Number 2
BKCSDE 25(2)
February 20, 2004 

A Convenient and Versatile Synthesis of 2\' (and 3\')-Amino (and azido)-2\' (and 3\')-deoxyadenosine as Diverse Synthetic Precursors of Cyclic Adenosine Diphosphate Ribose (cADPR)
Beom-Tae Kim, Seung-Ki Kim, Seung-Jae Lee, Ki-Jun Hwang*
Cyclic adenosine diphosphate ribose (cADPR), 2' (and 3')-Amino (and azido)- 2' (and 3')-deoxyadenosine
As diverse synthetic precursors of cyclic adenosine diphosphate ribose (cADPR), several adenosine derivatives in which azido or amino group is introduced at 2'- or 3'-position of the sugar moiety of adenosine were prepared from readily available adenosine via conventional protocols. These synthetic sequence employs very efficient reactions conditions that proceed at or below ambient temperature with actual yields of >80% for each individual step.
243 - 248
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