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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 24, Number 10
BKCSDE 24(10)
October 20, 2003 

Protein Tyrosine Phosphatase 1B Inhibitors: Heterocyclic Carboxylic Acids
Sung Yun Cho, Jin Hee Ahn, Jae Du Ha, Seung Kyu Kang, Ji Yoen Baek, Sang Sub Han, Eun Young Shin, Sung Soo Kim, Kwang Rok Kim, Hyae Gyeong Cheon, Joong-Kwon Choi
Diabetes, PTP1B inhibitor, Isoxazole, Oxadiazole, Quinoline
Several series of compounds (benzoic acids, pyrazolecarboxylic acids, phenoxyacetic acids, and quinolinoxyacetic acids) were prepared and evaluated for their inhibitory activity against PTP-1B. Several compounds showed submicromolar inhibitory activity.
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