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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 24, Number 5
BKCSDE 24(5)
May 20, 2003 

Isolation and Synthesis of Tryptamine Derivatives from a Symbiotic Bacterium Xenorhabdus nematophilus PC
Seunguk Paik, Myung Kwang Park, Seong Hoon Jhun, Heai Ku Park, Chun Soo Lee, Bum Rae Cho, Hong Sik Byun, Seok Burm Choe, Seong Il Suh
Xenorhabdus nematophilus, Staphylococcus aureus, Nematophin, Tryptamine, L-Isoleucine
Nematophin and its analog incorporating tryptamine unit have been isolated and characterized from strain XRPC of a symbiotic bacterium Xenorhabdus nematophilus, which was newly isolated from Korean entomopathogenic nematodes. The stereoselective synthesis of these compounds was accomplished, and the relative configurations were determined. Nematophin exhibited potent antibacterial activities over several strains of methicillin-resistant S. aureus (MRSA) comparable to those of vancomycin.
623 - 626
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