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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 23, Number 12
BKCSDE 23(12)
December 20, 2002 

Synthesis and Preliminary Biological Studies of Novel Retinamide Derivatives
Hong S. Sin, Youn J. Kwon, Hye S. Han, Si H. Park, Moong S. Park, Young S. Rho, Soo J. Um
4-HPR, Retinoid, Derivatives, Side chain, Biological studies
We have described the synthesis and biological activity of novel retinamide derivatives. The retinamide derivatives were synthesized by introducing functional side chains into the 4-hydroxy group of 4-HPR. The activities could be dependent on the side chain length, functional group, and hetero atom. The antiprolife-rative potential of the derivatives was assessed by MTT assay in HCT116 colon cancer cell lines.
1806 - 1810
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