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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 23, Number 12
BKCSDE 23(12)
December 20, 2002 

Synthesis and Reactions of New Thienopyridines, Pyridothienopyrimidines and Pyridothienotriazines
E. A. Bakhite, A. E. Abdel-Rahman, O. S. Mohamed, E. A. Thabet
Thienopyridines, Pyrimidines, Triazines
4-Aryl-3-cyano-6-(2'-thienyl)-pyridine-2(1H)-thiones (1a-c) were reacted with phenacyl bromide, chloro-N-arylacetamides or 2-chloroacetylaminopyridine to furnish 2-functionalized 3-amino-4-aryl-6-(2'-thienyl)-thieno[2,3-b]pyridines 4a-c and 5a-c or 5d respectively. The compounds 5a-d underwent different sequence of reactions to produce a variety of thienylpyridothienopyrimidines and, thienylpyridothienotriazines. Some of the prepared compounds were tested in vitro for their antimicrobial activities.
1709 - 1714
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