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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 22, Number 11
BKCSDE 22(11)
November 20, 2001 
 
Title
 Synthesis and SAR of Benzimidazole Derivatives Containing Oxycyclic Pyridine as a Gastric H+/K+ -ATPase Inhibitors
Author
 Sung Yun Cho, Seung Kyu Kang, Sung Soo Kim, Hyae Gyeong Cheon, Joong-Kwon Choi, Eul Kgun Yum, Ki-Jun Hwang
Keywords
 Benzimidazole, Oxycyclic pyridine, Gastric H+/K+-ATPase inhibitor.
Abstract
 A series of benzimidazole derivatives containing oxycyclic pyridine was prepared and evaluated for their gastric H+ /K+ -ATPase inhibitory activity. Several of the synthesized compound exhibited potent antisecretion in pylorus-ligated rats when administered intradoudenally. Their inhibitory activities were equivalent or comparable to omeprazole.
Page
 1217 - 1223
Full Text
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