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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 22, Number 10
BKCSDE 22(10)
October 20, 2001 

Inhibitory Effect of Methyl Caffeate on Fos-Jun-DNA Complex Formation and Suppression of Cancer Cell Growth
Soon Pyo Lee, Gyo Jun, Eun-Jin Yoon, Seyeon Park, Chul-Hak Yang
AP-1 binding site, Fos-Jun heterodimer, P. frutescens, Methyl caffeate, Dibutyl phthalate (DBP).
The fos and jun proteins form a heterodimeric complex that interacts with the DNA regulatory element known as the AP-1 binding site. To search for inhibitors of the fos-jun-DNA complex formation, several natural plants extracts were screened. One of them, the methanol extract of Perilla frutescens showed inhibitory effect against the complex formation between the fos-jun dimer and the AP-1 binding site (TGAG/CTCA). Methyl caffeate and dibutyl phthalate (DBP) were isolated as the active constituents from the extract of P. frutescens by repeated column chromatography and HPLC. And their IC50 values for fos-jun-DNA complex formation were estimated as 0.29 mM and 0.55 mM, respectively. The more potent inhibitor, methyl caffeate showed cytotoxic effect against human cancer cell line (A549 and K562).
1131 - 1135
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