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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 22, Number 10
BKCSDE 22(10)
October 20, 2001 

Transformation of Carboxylic Acid Salts to Aldehydes by Stepwise Reduction with Borane and Oxidation with Pyridinium Chlorochromate
Jin Soon Cha, Jae Hyung Park, Suk Joung Moon
Stepwise reduction-oxidation, Borane reduction, PCC oxidation, Conversion of carboxlic acid salts to aldehydes, Aldehyde synthesis.
The stepwise reduction-oxidation method has been successfully applied to conversion of carboxylic acid salts to the corresponding aldehydes. Thus, both sodium and lithium salts of carboxylic acid were readily converted to aldehydes in essentially quantitative yields by stepwise treatment with borane and dimethyl sulfate, and followed by oxidation with PCC. Alternatively, the treatment of acid salts with two equivalents of borane in THF, and followed by the oxidation also provided the same results.
1089 - 1092
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