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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 22, Number 5
BKCSDE 22(5)
May 20, 2001 

An Efficient and Eco-friendly Approach to 15 N-Unsubstituted β-Lactams: 15 N-Labled Synthons for Taxol and Its Analogs
Sang Hyun Park, Sang Yup Lee, Ajay K. Bose
15N-Labled synthons for taxol, 15N-Unsubstituted b-lactams.
An efficient and eco-friendly approach to N-unsubstituted β-lactams has been developed using mostly water as the reaction medium. This methodology was applied to the synthesis of N-unsubstituted 3-hydroxy-4-phenyl-2-azetidinone derivatives (including 15N-labeled version) which are suitable precursors for the C-13 side chain of taxol and its analogs.
493 - 498
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