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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 22, Number 5
BKCSDE 22(5)
May 20, 2001

Title	An Efficient and Eco-friendly Approach to ¹⁵ N-Unsubstituted β-Lactams: ¹⁵ N-Labled Synthons for Taxol and Its Analogs
Author	Sang Hyun Park, Sang Yup Lee, Ajay K. Bose
Keywords	15N-Labled synthons for taxol, 15N-Unsubstituted b-lactams.
Abstract	An efficient and eco-friendly approach to N-unsubstituted β-lactams has been developed using mostly water as the reaction medium. This methodology was applied to the synthesis of N-unsubstituted 3-hydroxy-4-phenyl-2-azetidinone derivatives (including ¹⁵N-labeled version) which are suitable precursors for the C-13 side chain of taxol and its analogs.
Page	493 - 498
Full Text	PDF

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