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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 21, Number 10
BKCSDE 21(10)
October 20, 2000 

 
Title
Synthesis of Water-soluble Methoxyethoxy-Aminoarlyoxy Cosubstituted Polyphosphazenes as Carrier Molecules for Bioactivc Agents
Author
Suk-Ky Kwon
Keywords
Abstract
The water-soluble poly(methoxyethoxy-aminoarlyoxy phosphazene) has been synthesized and investigated as a polymeric carrier molecule for the covalent attachment of bioactive agents. The synthetic procedures were developed first through the use of cyclic trimeric model systems. These model systems were utilized for the synthesis of polymeric analogues containing bioactive side groups. The sodium salts of 2-methoxyethanol and 4-acetamidophenol were allowed to react with (NPCl₂)₃ or (NPCl₂)n or to yield derivatives of type [NP-(OCl₂CH₂CH₂OCH₃)χ(OArNHCOCH₃)y]₃or n. The 4-acetamido groups were then hydrolyzed to 4-amino-phenoxy units with potassium tert-butoxide. Coupling reactions between amino group and N-acetylglycine was accomplished with the use of dicyclohexylcarbodiimide. Their properties and structural characterization are discussed.
Page
969 - 972
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